What is a common gastrointestinal side effect of ibuprofen?

What is a common gastrointestinal side effect of ibuprofen?

• A. Constipation
• B. Diarrhoea
• C. Indigestion
• D. Flatulence

Answer: (B)

The gastrointestinal side effect commonly associated with ibuprofen is indigestion. Ibuprofen, a non-steroidal anti-inflammatory drug (NSAID), can irritate the stomach lining, leading to discomfort, heartburn, and a sensation of fullness or bloating. This is due to ibuprofen's inhibition of prostaglandin synthesis, which plays a crucial role in maintaining the protective mucosal layer of the gastrointestinal tract. When prostaglandin levels decrease because of NSAID use, it can predispose the stomach to irritation and subsequent symptoms of indigestion. While conditions like constipation, diarrhea, and flatulence can occur with various medications or dietary changes, they are not the primary concerns with ibuprofen. Indigestion is specifically noted in various clinical resources as a common side effect, emphasizing the drug's gastrointestinal implications. Understanding this aspect is crucial for anyone administering ibuprofen, as it helps manage potential side effects effectively.

The gastrointestinal side effect commonly associated with ibuprofen is indigestion. Ibuprofen, a non-steroidal anti-inflammatory drug (NSAID), can irritate the stomach lining, leading to discomfort, heartburn, and a sensation of fullness or bloating. This is due to ibuprofen's inhibition of prostaglandin synthesis, which plays a crucial role in maintaining the protective mucosal layer of the gastrointestinal tract. When prostaglandin levels decrease because of NSAID use, it can predispose the stomach to irritation and subsequent symptoms of indigestion.

While conditions like constipation, diarrhea, and flatulence can occur with various medications or dietary changes, they are not the primary concerns with ibuprofen. Indigestion is specifically noted in various clinical resources as a common side effect, emphasizing the drug's gastrointestinal implications. Understanding this aspect is crucial for anyone administering ibuprofen, as it helps manage potential side effects effectively.